The first issue of World Journal of Stem Cells (WJSC ), whose preparatory work was initiated on September 27, 2008, will be published on December 31, 2009. The WJSC Editorial Board has now been established and consists of 281 distinguished experts from 28 countries. Our purpose of launching WJSC is to publish peer-reviewed, high-quality articles via an open-access online publishing model, thereby acting as a platform for communication between peers and the wider public, and maximizing the benefits to editorial board members, authors and readers.