指向白血病干细胞: 在成年尖锐 myeloid 的治疗的新目标白血病

• 作者: Xavier Thomas
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: ACUTE MYELOID LEUKEMIA LEUKEMIA stem cells TARGETED therapy PROGNOSIS
• 年，卷（期）: 2009,（1）
• 页码范围: 49-54
• 页数: 6页
• 分类号: R733.7

摘要

The most popular view of hematopoietic cell lineage organization is that of complex reactive or adaptative systems.Leukemia contains a subpopulation of cells that display characteristics of stem cells.These cells maintain tumor growth.The properties of leukemia stem cells indicate that current conventional chemotherapy, directed against the bulk of the tumor,will not be effective.Leukemia stem cells are quiescent and do not respond to cell cycle-specific cytotoxic agents used to treat leukemia and thus contribute to treatment failure. New strategies are required that specifically target this malignant stem cell population.