BIOINFORMATICS RESEARCH ON CHRONIC SUPERFICIAL GASTRITIS OF PI-DEFICIENCY SYNDROME BY GENE ARRAYS

• 来源期刊: 中国结合医学杂志(英文版)
• 学科: 医学
• 年，卷（期）: 2009,（5）
• 页码范围: 341-346
• 页数: 6页
• 分类号: R573.3
• 语种: 中文

摘要

Objective:To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis(CSG) with the Pi-deficiency syndrome(PDS) and those of the non-Pi -deficiency syndrome(non-PDS),i.e.patients of CSG with Pi(脾)-Wei(胃) dampnese-heat syndrome and healthy persons.Methods:With the BRB-Array Tools software package,original data collection and bioinformatic analysis of gene arrays were conducted in 6 CSG patients of PDS(CSG-PDS),6 CSG patients of non-PDS (CSG-nPDS),and 6 healthy volunteers(Normal).Results:Compared with non-PDS,the gene expressions in PDS with regards to protein synthesis,energy metabolism,immune reaction and ionic transport tended to be down-regulated,while those concerning secretion,cytoskeleton and ubiquitinization were up-regulated dominantly.Conclusions:The two kinds of samples,CSG-PDS/Normal and CSG-PDS/CSG-nPDS,have their respective gene expression profiles with different characteristics.Gene expression profile has certain referential significance in syndrome classification.