从骨胳的肌肉的联系容器的干细胞: 从生物学到在房间治疗的未来使用

• 作者: Cristina Sancricca Massimiliano Mirabella Carla Gliubizzi Aldobrando Broccolini Teresa Gidaro Roberta Morosetti
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: SKELETAL MUSCLE Mesoangioblasts Vessel-associated progenitors STEM CELLS
• 年，卷（期）: 2010,（3）
• 页码范围: 39-49
• 页数: 11页
• 分类号: R685

摘要

Over the last years,the existence of different stem cells with myogenic potential has been widely investigated.Be-sides the classical skeletal muscle progenitors represented by satellite cells,numerous multipotent and embryologi-cally unrelated progenitors with a potential role in muscle differentiation and repair have been identified.In order to conceive a therapeutic approach for degenerative muscle disorders,it is of primary importance to identify an ideal stem cell endowed with all the features for a possible use in vivo.Among all emerging populations,vessel-associated stem cells are a novel and promising class of multipotent progenitors of mesodermal origin and with high myogenic potential which seem to best fit all the requirements for a possible cell therapy.In vitro and in vivo studies have already tested the effectiveness and safety of vessel-associated stem cells in animal models.This leads to the concrete possibility in the future to start pilot human clinical trials,hopefully opening the way to a turn-ing point in the treatment of genetic and acquired muscle disorders.