胚胎、成年的干细胞的免疫学的性质

• 作者: Francesco Bifari Luciano Pacelli Mauro Krampera
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Immune suppression EMBRYONIC STEM CELLS MESENCHYMAL STEM CELLS IMMUNOGENICITY REGENERATIVE medicine Neural STEM CELLS
• 年，卷（期）: 2010,（3）
• 页码范围: 50-60
• 页数: 11页
• 分类号: R329

摘要

The possibility of treating degenerative diseases by stem cell-based approaches is a promising therapeutical option.Among major concerns for the clinical application of stem cells,some derive from the possibility that stem cells may be rejected by the immune system as a consequence of histoincompatibility and that stem cells themselves may interfere with the normal functions of host immune response.Therefore,the immunogenicity and the immunomodulatory properties of stem cells must be carefully addressed.Although these properties are common features of different stem cell types,some peculiarities can be recognized and characterized for their proper clinical use.