nephrogenic 的 Pathophysiology 全身的纤维变性: 试验性的数据的评论

• 作者: John Haylor Sameh K Morcos
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Experimental models Gadolinium-based CONTRAST agents Nephrogenic SYSTEMIC FIBROSIS PATHOPHYSIOLOGY
• 年，卷（期）: 2010,（11）
• 页码范围: 427-433
• 页数: 7页
• 分类号: R692

摘要

Since the association between nephrogenic systemic fibrosis(NSF) and gadolinium contrast agents(Gd-CAs) was suggested in 2006,several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF.Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells.Low stability agents have also induced NSFlike skin changes in a rat model with normal renal function after multiple repeat administrations.The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation.