Henoch-Schnlein purpura complicating adalimumab therapy for Crohn’s disease

• 作者: Anna Shepherd Farooq Z Rahman Gagandeep K Takhar Ovishek Roy Sara A McCartney Stuart L Bloom
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Henoch-Schnlein purpura ADALIMUMAB Anti-TNF THERAPY Leukocytoclastic vasculitis Crohn’s disease
• 年，卷（期）: 2010,（5）
• 页码范围: 119-122
• 页数: 4页
• 分类号: R574

摘要

Anti-tumour necrosis factor-α(TNF) therapy has revolutionised the management of chronic inflammatory conditions.With ever increasing numbers of patients being treated with these agents,uncommon adverse reactions will inevitably occur more frequently.Cutaneous manifestations are associated with many of these chronic conditions and can complicate anti-TNF therapy in about 20% of cases.Vasculitic complications are rarely associated with anti-TNF therapy.Henoch-Schnlein purpura(HSP),a small vessel vasculitis,has been described following infliximab and etanercept therapy but never with adalimumab,a fully humanized TNF antibody.The risk of such immune-mediated reactions is theoretically less with adalimumab compared to infliximab but can still occur.Here we report the f irst case in the literature of HSP that can be attributed to the use of adalimumab in a 19-year-old male with recalcitrant Crohn’s disease.