Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis

• 作者: Alirio J Melendez Bernard P Leung
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: CYTOKINES Inflammation RHEUMATOID ARTHRITIS SPHINGOSINE KINASE Sphingosine-1-phosphate
• 年，卷（期）: 2010,（11）
• 页码范围: 321-326
• 页数: 6页
• 分类号: R684

摘要

The importance of sphingosine kinase(SphK)and sphingosine-1-phosphate(S1P)in inflammation has been extensively demonstrated.As an intracellular second messenger,S1P plays an important role in calcium signaling and mobilization,and cell proliferation and survival.Activation of various plasma membrane receptors,such as the formyl methionyl leucyl phenylalanine receptor,C5a receptor,and tumor necrosis factor α receptor,leads to a rapid increase in intracellular S1P level via SphK stimulation.SphK and S1P are implicated in various chronic autoimmune conditions such as rheumatoid arthritis, primary Sjgren’s syndrome,and inflammatory bowel disease.Recent studies have demonstrated the important role of SphK and S1P in the development of arthritis by regulating the pro-inflammatory responses.These novel pathways represent exciting potential therapeutic targets.