Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein

• 作者: Fumikazu Okajima Koichi Sato
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HIGH-DENSITY LIPOPROTEIN SPHINGOSINE 1-phosphate SCAVENGER receptor class B typeⅠ Antiatherogenic ACTIONS
• 年，卷（期）: 2010,（11）
• 页码范围: 327-337
• 页数: 11页
• 分类号: R363

摘要

The reverse cholesterol transport mediated by highdensity lipoprotein(HDL)is an important mechanism for maintaining body cholesterol,and hence,the crucial anti-atherogenic action of the lipoprotein.Recent studies,however,have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism.The present review provides an overview of the roles of sphingosine 1-phosphate(S1P)/S1P receptor and apolipoprotein A-I/ scavenger receptor class B typeⅠsystems in the antiatherogenic HDL actions.In addition,the physiological significance of the existence of S1P in the HDL particles is discussed.