Pericarditis and chronic inflammatory demyelinating polyneuropathy during therapy with pegylated interferon alfa-2a for chronic hepatitis C

• 作者: Kazuaki Nishio Machiko Enchi Shunichi Okada Takeshi Konndo
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: CHRONIC HEPATITIS C CHRONIC inflammatory DEMYELINATING POLYNEUROPATHY PEGINTERFERON alfa-2a PERICARDITIS
• 年，卷（期）: sjgbxzzywbdzb_2010,（9）
• 页码范围: 358-361
• 页数: 4页
• 分类号: R512.63

摘要

We report a case of pericarditis and chronic inflam- matory demyelinating polyneuropathy with biological signs of a lupus-like syndrome due to pegylated interferon alfa-2a therapy during treatment for chronic hepatitis C.The patient developed moderate weakness in the lower limbs and dyspnea.He was hospitalized for congestive heart failure.An electrocardiogram showed gradual ST-segment elevation in leads V1 through V6 without coronary artery disease.A transthoracic cardiac ultrasonographic study revealed moderate pericardial effusion with normal left ventricular function.Anti-DNA antibody and anti-ds DNA IgM were positive.Neu ro logical examination revealed a symmetrical predomina ntly sensory polyneuropathy with impairment of light touch and pin prick in globe and stoking-like distribution.Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.