multipotent 的有免疫力的规章的性质间充质的 stromal 房间: 我们在哪儿站？

• 作者: ênio José Bassi Carlos Alberto Mayora Aita Niels Olsen Saraiva Camara
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: IMMUNOSUPPRESSION MESENCHYMAL stem cell Immune system Inflammation AUTOIMMUNE disease
• 年，卷（期）: 2011,（1）
• 页码范围: 1-8
• 页数: 8页
• 分类号: R329

摘要

Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of surface expression of costimulatory molecules required for complete T cell activation. Recently, it has been observed that MSC are capable of suppressing the immune response by inhibiting the maturation of dendritic cells and suppressing the function of T lymphocytes, B lymphocytes and natural killer cells in autoimmune and inflammatory diseases as a new strategy for immunosuppression. The understanding of immune regulation mechanisms by MSC is necessary for their use as immunotherapy in clinical applications for several diseases.