A Simple and Highly Efficient Enantioselective Synthesis of (<i>S</i>)-Rivastigmine

• 作者: Laxminarasimhulu Gorentla Pramod K. Dubey Veera R. Arava
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: CHOLINERGIC Agent ENANTIOSELECTIVE Highly Efficient (S)-(-)-2-Methyl-2-Propane Sulfina-mide (S)-Rivastigmine
• 年，卷（期）: yjhxgjqkyw,（2）
• 页码范围: 26-32
• 页数: 7页
• 分类号: O62

摘要

A highly efficient and convenient procedure for the enantioselective synthesis of (S)-Rivastigmine, a cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson’s disease, is accomplished by the treatment of versatile, readily accessible (S)-(-)-2-methyl-2-propanesulfinamide with 3-hydroxyacetophenone. This protocol provides high yield and excellent enantiomeric excess in short step synthesis.