在在长期的眼睛的高血压老鼠的视网膜的 HIF-1 和 iNOS 的表示上的 erythropoietin 的效果

• 作者: and Dian-Wen Gao Dong-Mei Gui Xun Li Yang Yang
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: EPO HIF-1 INOS OCULAR hypertension RETINA
• 年，卷（期）: 2011,（1）
• 页码范围: 40-43
• 页数: 4页
• 分类号: R775

摘要

AIM:To research the effect of erythropoietin(EPO) to the HIF-1\iNOS signal transduction path in retina in chronic ocular hypertension rat.· METHODS:One hundred and twenty Wistar rats were divided into 12 groups randomly.Two episcleral veins were coagulated unilaterally in rats with electric coagulator to establish the glaucoma model.PT-PCR and Western Blot analysis were used to examine the expression of Caspase-9 genes in retina.And the changes of ERG-b wave before and after were detected using EPO.· RESULTS:In EPO drug treatment group,the amplitude of ERG-b wave of retina restored remarkably.There was significant difference between two groups(P【0.05).The expression of HIF-1\iNOS mRNA and protein in EPO drug treatment group were weakened remarkably.It was statistically different compared with the non-drug treatment group.· CONCLUSION:One of protect mechanisms of EPO to injured retina caused by chronic intraocular hypertension is through HIF-1\iNOS signal conduct path.