Two Flavones from <i>Acanthospermum hispidum</i>DC and Their Antibacterial Activity

• 作者: Abass A. Olajire Theresa I. Edewor
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 医学
• 关键词: Acanthospermum hispidum DC FLAVONOIDS ANTIBACTERIAL SPECTROSCOPY
• 年，卷（期）: yjhxgjqkyw_2011,（3）
• 页码范围: 132-141
• 页数: 10页
• 分类号: R28

摘要

Two new flavones, namely 5,7,2’,5’-tetrahydroxy-3,4’-dimethoxyflavone and 5’-acetoxy-5,7,2’-trihydroxy-3, 4’-dimethoxyflavone were successfuly isolated from the leaves of Acanthospermum hispidum DC and identified by UV-Vis, IR, 1H-NMR and EI-MS techniques. Both compounds exhibited antibacterial activity against Salmonella typii, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Bacillus subtilis, Pseudomonas aeruginosa and Shigella dysenteriae with minimum inhibition concentration (MIC) ranging from 0.001 - 0.20 but was inactive against Escherichia coli, Corybacterium pyogenes and Proteus vulgaris.