在肠胃病学的 bioflavonoids 的新兴的角色: 特别肠的瘤形成上的他们的效果

• 作者: Harald P Hoensch Reinhard Oertel
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Flavonoids Intestinal neoplasia CANCER prevention APIGENIN EPIGALLOCATECHIN GALLATE Inhibition of colon CANCER cells
• 年，卷（期）: 2011,（5）
• 页码范围: 71-74
• 页数: 4页
• 分类号: R735

摘要

Flavonoids,secondary plant products which could be essential for normal physiology in humans and animals,may be the vitamins of the next century.Flavonoids belong to the polyphenols and possess antioxidative,anti-inflammatory,antimutagenic and anticarcinogenic properties.Among the various flavonoid species,tea flavonoids such as apigenin (from camomile) and epigallocatechin gallate (EGCG from green tea) can be used for the prevention of intestinal neoplasia,especially for adenoma and cancer prevention in the gastrointestinal tract.Numerous experimental studies with molecular and biological end points support the therapeutic efficacy of bioflavonoids.Clinical studies with cohorts and case-control trials suggest that flavonoids are effective in tertiary bioprevention but,as yet,there are no controlled randomized clinical trials.Flavonoids can inhibit inflammatory pathways and could be useful for chronic inflammatory bowel diseases.Flavonoid deficiency syndromes could be therapeutic targets in the future.