Up a lymphoid blind alley:Does CALM/AF10 disturb Ikaros during leukemogenesis?

• 作者: Philipp A Greif Stefan K Bohlander
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: ACUTE lymphoblastic LEUKEMIA ACUTE MYELOID LEUKEMIA CALM/AF10 Chronic MYELOID LEUKEMIA IKAROS
• 年，卷（期）: 2011,（6）
• 页码范围: 115-118
• 页数: 4页
• 分类号: R733.7

摘要

The Ikaros gene is required for normal development of lymphocytes and frequent intragenic deletions of Ikaros have been identified in acute lymphoblastic leukemia.However,little is known about the role of Ikaros in myeloid malignancies.Here we discuss the role of Ikaros as a lineage master regulator during the onset and progression of myeloid leukemias,namely CALM-AF10 positive acute myeloid leukemia and chronic myeloid leukemia.Alterations of Ikaros at the gene or protein level may act as a bi-directional lineage switch subverting developmental plasticity for malignant transformation.Finally,we propose that promiscuous signaling involving Ikaros and FOXO transcription factors might be a critical link between early lineage fate and uncontrolled proliferation.