The use of bee venom as a therapeutic agent for the relief of joint pains dates back to Hippocrates,and ref-erences to the treatment can be found in ancient Egyp-tian and Greek medical writings as well.Also known as apitherapy,the technique is widely used in Eastern Europe,Asia,and South America.The beneficial effects of bee stings can be attributed to mellitinin,an anti-in-flammatory agent,known to be hundred times stronger than cortisone.Unfortunately,certain substances in the bee venom trigger allergic reactions which can be life threatening in a sensitized individual.Multiple stings are known to cause hemolysis,kidney injury,hepatotoxicity and myocardial infarction.The toxicity can be immedi-ate or can manifest itself only weeks after the exposure.We describe hepatotoxicity in a 35-year-old female,following bee sting therapy for multiple sclerosis.She presented to our clinic 3 wk after therapy with a his-tory of progressive jaundice.The patient subsequently improved,and has been attending our clinic now for the last 9 mo.