有 variceal 破裂的进步的肝肉状瘤的一个组织学地证明的盒子

• 作者: Chie Morioka Hiroshi Fukui Hitoshi Yoshiji Keisuke Na-kanishi Kou Kitagawa Masahito Uemura Ryuichi Noguchi Yasuhide Ikenaka Yosuke Aihara Yusaku Shirai
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: LIVER SARCOIDOSIS PORTAL HYPERTENSION He-patic FAILURE LIVER CIRRHOSIS
• 年，卷（期）: 2011,（10）
• 页码范围: 271-274
• 页数: 4页
• 分类号: R575

摘要

Sarcoidosis is a chronic multi-systemic granulomatous disease,and liver involvement frequently occurs.in most cases,no evidence of liver dysfunction is ob-served,and portal hypertension due to sarcoid liver diseases is a rareoccurrence.Moreover,no case of liver sarcoidosis has ever been reported with confirma-tion of the disease progression.Herein we describe a patient having hepatic sarcoidosis with severe portal hypertension and liver dysfunction.The diagnosis was histologically confirmed from granulomatous status to established liver cirrhosis over 10 years.A 46-year-old woman developed massive hematemesis due to the rupture of gastric cardial varices.She underwent emer-gency endoscopic injection sclerotherapy,and clear evi-dence of chronic hepatic failure.Twelve years ago,she was diagnosed as having sarcoidosis with respiratoryclinicalsymptoms.Liver biopsy revealed asymptomatic incidental granulomas without fibrosis development.After a couple of years,features of liver dysfunction were manifest and progressed.Ten years after the first biopsy,a second liver biopsy was performed,and well established dense fibrosis was revealed.Although significant liver dysfunction with portal hypertension is rarely seen in sarcoidosis,this case indicates that we have to consider the possibility that sarcoidosis may cause end-stage liver cirrhosis.