Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats

• 作者: Junichi Hada Kousuke Honda Makoto Hasegawa Masahiro Urade Nao Ohtsu Tetsuya Abe
• 来源期刊: 神经系统科学与医药(英文)
• 学科: 医学
• 关键词: CYCLOOXYGENASE-2 (COX-2) ETODOLAC FEAR Memory HIPPOCAMPAL BLOOD Flow Mean Arterial BLOOD Pressure Tooth Pulp STIMULATION
• 年，卷（期）: 2011,（3）
• 页码范围: 295-298
• 页数: 4页
• 分类号: R73

摘要

In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.