对在用加速的 hypofractionated 放射疗法的乳癌的治疗的 contralateral 乳腺剂量的评价

• 作者: Andreas Foteineas Anna Zygogianni John Kouvaris Kalliopi Platoni Maria Dilvoi Maria Tolia Maria-Aggeliki Kalogeridi Mariangela Caimi Niki Margari Nikolaos Tsoukalas Panagiotis Pantelakos Vassilis Kouloulias
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: BREAST cancer HYPOFRACTIONATION CONTRALATERAL BREAST DOSE calculation
• 年，卷（期）: 2011,（9）
• 页码范围: 233-240
• 页数: 8页
• 分类号: R737.9

摘要

AIM:To measure the dose distribution,related to the treatment planning calculations,in the contralateral mammary gland of breast cancer patients treated with accelerated hypofractionated 3-dimensional conformal radiotherapy.METHODS:Thirty-four prospectively selected female patients with right breast cancer (pN0,negative surgical margins) were treated with breast-conserving surgery.A total dose of 42.5 Gy (2.66 Gy/fraction) was prescribed;it was requested that planning target volumes be covered by the 95% isodose line.The contralateral mam-mary gland was defined on CT simulation.The dose received was evaluated by dose volume histograms.RESULTS:The measured contralateral breast doses were:(1) Dose maximum:290-448 cGy [Equivalent (Eq) 337-522 cGy];(2) Mean dose:45-70 cGy (Eq 524815 cGy);and (3) Median dose:29-47 cGy (337-547 cGy) for total primary breast dose of 42.5 Gy in 16 equal fractions.The spearman rho correlation showed statistical significance between the contralateral breast volume and maximum dose (P=0.0292),as well as mean dose (P=0.0025) and median dose (P=0.046) to the breast.CONCLUSION:Minimizing the dose to the contralateral breast has to be one of the priorities of the radiation oncologist when using short schedules because of the radiosensitivity of this organ at risk.Further study is necessary to assess the long-term clinical impact of this schedule.