Role of Tip60 tumor suppressor in DNA repair pathway

• 来源期刊: 科学通报(英文版)
• 学科: 医学
• 年，卷（期）: 2011,（12）
• 页码范围: 1212-1215
• 页数: 4页
• 分类号: R341
• 语种: 中文

摘要

To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms. The ubiquitously expressed acetyltransferase, Tip60, plays a central role in ATM (ataxia-telangiectasia mutated) activation which is involved in DNA repair. Recent work uncovered a new mechanism of ATM activation mediated by Tip60 and demonstrated that histone methylation, specifically, trimethylation of histone H3, is a key factor in the process. Here, we review the current understanding of how Tip60 is activated and how it activates ATM in response to DNA damage.