Viable mice produced from three-factor induced pluripotent stem(iPS)cells through tetraploid complementation

• 来源期刊: 细胞研究(英文版)
• 学科: 生物学
• 年，卷（期）: 2011,（3）
• 页码范围: 546-549
• 页数: 4页
• 分类号: Q2
• 语种: 中文
• DOI: 10.1038/cr.2010.164

摘要

Dear Editor, Ectopic expression of four transcription factors, including Oct4, Sox2, Klf4 and c-Myc, in differentiated fibroblast cells could reset the cell fate of fibroblast cells to pluripotent state[1].Subsequently, full pluripotency of these so-called induced pluripotent stem cells (iPSCs)has been demonstrated, as viable mice could be generated autonomously from iPSCs through tetraploid blastocyst complementation [2, 3].Moreover, the generation of human and patient-specific iPSCs has raised the possibility of utilizing iPSCs clinically [4-6].However, the utilization of c-Myc in iPSC induction greatly increased the incidence of tumorigenecity in the iPS-chimeric mice and also might hinder the clinical application of human iPSCs in the future [7].