Endophenotype strategies for the study of neuropsychiatric disorders: A quest

• 来源期刊: 科学通报(英文版)
• 学科: 医学
• 年，卷（期）: 2011,（32）
• 页码范围: 3359-3360
• 页数: 2页
• 分类号: R749
• 语种: 中文

摘要

The identification of genes that contribute to the susceptibilities to complex neuropsychiatric disorders such as schizophrenia, major depression and bipolar disorders has not been as successful using conventional genetic approaches as had been hoped. There are several problems associated with the conventional approaches, including the validity of psychiatric diagnosis itself, excluding carriers of relevant genes who cannot be identified in the absence of manifest symptoms, and the heterogeneity of