Dermatitis herpetiformis:Novel advances and hypotheses

• 作者: Emiliano Antiga Marzia Caproni Paolo Fabbri
• 来源期刊: 世界皮肤病学杂志
• 学科: 医学
• 关键词: DERMATITIS herpetiformis CELIAC disease TRANSGLUTAMINASE GLUTEN-FREE DIET Direct IMMUNOFLUORESCENCE
• 年，卷（期）: 2012,（3）
• 页码范围: 24-29
• 页数: 6页
• 分类号: R

摘要

Dermatitis herpetiformis(DH)is a gluten-sensitive autoimmune blistering disorder with a chronic-relapsing course.Very recently,several Authors reported atypical cases of patients with DH,suggesting that different clinical subsets may exist at least among different ethnicities and that the classical picture of DH probably need a significant revision.Moreover,different pathogenetic aspects of the disease are currently under investigation,including the role of epidermal transglutaminase,apoptosis and inflammatory cells in the occurrence of skin lesions,in order to explain why only a subgroup of celiac patients will develop DH.Finally,although glutenfree diet is still regarded as the only curative approach to the disease,it is very hard to comply with and even small amounts of gluten can re-activate the disease.Therefore,different therapeutical approaches for the spectrum DH/celiac disease are still under investigation.In the present paper,the most recent advances in DH will be discussed,and a novel interpretation of the disease based on the data emerging from the Literature will be proposed.