TsOH·H<sub>2</sub>O-Catalyzed Friedel-Crafts of Indoles of 3-Hydroxyisobenzofuran-1(3<i>H</i>)-One with Indoles: Highly Synthesis of 3-Indolyl-Substituted Phthalides

• 作者: Airu Song Hongying Tang Xinyu Zhang Zhongbiao Zhang
• 来源期刊: 催化剂现代研究(英文)
• 学科: 化学
• 关键词: Synthesis 3-Indolyl-Substituted PHTHALIDES FRIEDEL-CRAFTS Alkylation 3-Hydroxyisobenzofuran-1(3H)-One Indole
• 年，卷（期）: 2012,（2）
• 页码范围: 11-14
• 页数: 4页
• 分类号: O6

摘要

An efficient and facile method for the synthesis of 3-indolyl-substituted phthalides by Friedel-Crafts alkylation of indoles with 3-hydroxyisobenzofuran-1(3H)-one has been developed. Using only 2 mol-% TsOH·H2O as the catalyst, various substituted indoles can react smoothly at room temperature to give the corresponding phthalides products in good to excellent yields (up to 96%).