Antioxidant Protective Effects of the Resveratrol on the Cardiac and Vascular Tissues from Renal Hypertensive Rats

• 作者: Angélica Cristina Scalabrini Carla Renata Kitanish Antonietto Carolina Baraldi Araujo Restini José Wilson N. Corrêa Joyce Cristina de Oliveira Larissa Pernomian Talita Sanches Marinho
• 来源期刊: 药物化学期刊(英文)
• 学科: 医学
• 关键词: Hypertension AORTA Superoxide RESVERATROL PHENYLEPHRINE REACTIVE Species of Oxygen (ROS)
• 年，卷（期）: 2012,（3）
• 页码范围: 61-71
• 页数: 11页
• 分类号: R73

摘要

Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.