Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease

• 作者: Angelo M. Scanu Celina Edelstein Diana M. Stafforini
• 来源期刊: 美国分子生物学期刊(英文)
• 学科: 医学
• 关键词: PLASMINOGEN Apolipoprotein(a) Lipoprotein(a) OXIDIZED PHOSPHOLIPIDS OXIDIZED PHOSPHATIDYLCHOLINES
• 年，卷（期）: 2012,（2）
• 页码范围: 110-112
• 页数: 3页
• 分类号: R5

摘要

Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form.