Formation of Photosensitizing Crystalline C<sub>60</sub>Particles by Ink-Jet Method

• 作者: Fusako Sasaki Masahito Ban
• 来源期刊: 纳米科学与工程(英文)
• 学科: 医学
• 关键词: FULLERENE Particle INK-JET REACTIVE Oxygen Species
• 年，卷（期）: 2012,（2）
• 页码范围: 110-115
• 页数: 6页
• 分类号: R73

摘要

The crystalline fullerene C60 particles were formed and immobilized on poly(dimethylsiloxane) (PDMS) substrates under the various discharge conditions by an ink-jet method, and investigated for the reactive oxygen species (ROS) generation property under visible light irradiation. The particles were synthesized by discharging a toluene solution dissolved C60 and poly(methyl methacrylate) (PMMA) with the ink-jet spotting system. The ROS generation was evaluated by comparisons of the fluorescence intensities measured for the formed particles under green laser irradiation and in a dark room using fluorescent dyes, 2’,7’-dichlorofluorescein diacetate and dihydroethidium. The results of transmission electron microscope (TEM) observation showed that the formed particles consisted of crystalline C60. The optimal ink-jet discharge conditions for synthesizing the particles to generate more ROS were found. In the case of the optimal conditions, the structure in which the needle-like particles were three-dimensionally formed was confirmed. The surface area of the crystalline C60 particles was calculated using the SEM observation results, and it was suggested that when the needle-like finer particles were three-dimensionally formed under the optimal conditions, increasing the surface area lead to an increase in the ROS generation amount.