New insights on the pathogenesis of pyloric stenosis of infancy. A review with emphasis on the hyperacidity theory

• 作者: Ian M. Rogers
• 来源期刊: 儿科学期刊(英文)
• 学科: 医学
• 关键词: Infantile Hypertrophic Pyloric stenosis (IHPS) Immunohistochemistry Smooth Muscle CELLS Gastrin MOTILIN Gastrointestinal MOTILITY ERYTHROMYCIN PYLOROMYOTOMY Acidification of the Stomach Pyloric Sphincter Function Receptor Binding Pathogenesis Antral MOTILITY Gastric Outflow Obstruction Linkage Analysis Single Nucleotide Polymorphism: Interstitial CELLS of Cahal Nitric Oxide Synthetase
• 年，卷（期）: 2012,（2）
• 页码范围: 97-105
• 页数: 9页
• 分类号: R5

摘要

A review is presented on the theories concerning the cause of pyloric stenosis with emphasis on the primary position of inherited hyperacidity in pathogenesis. Existing theories are critically analysed and the hyperacidity theory is precisely defined in the light of recent physiological insights into the gastrointestinal hormone motilin. The progressive fixed fasting hypergastrinaemia within the first few weeks of life will, in the baby who inherits acid secretion at the top of the normal range, produce hyperacidity of sufficient severity to trigger the process of acid-induced work hypertrophy of the pylorus. The potential contribution of motilin is discussed. The baby who inherits a normal gastric acidity will not reach acid levels severe enough to trigger sphincter hypertrophy despite the early gastrin stimulus. The potential threat will cease when gastrin naturally declines with age and the pyloric canal becomes wider. Genetic factors clearly must also be involved and these are separately discussed.