Peroxisomes,oxidative stress,and inflammation

• 作者: Courtney R Giordano Laura J Terlecky Stanley R Terlecky
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: PEROXISOMES OXIDATIVE STRESS INFLAMMATION
• 年，卷（期）: 2012,（5）
• 页码范围: 93-97
• 页数: 5页
• 分类号: R363

摘要

Peroxisomes are intracellular organelles mediating a wide variety of biosynthetic and biodegradative reactions.Included among these are the metabolism of hydrogen peroxide and other reactive species,molecules whose levels help define the oxidative state of cells.Loss of oxidative equilibrium in cells of tissues and organs potentiates inflammatory responses which can ultimately trigger human disease.The goal of this article is to review evidence for connections between peroxisome function,oxidative stress,and inflammation in the context of human health and degenerative disease.Dysregulated points in this nexus are identified and potential remedial approaches are presented.