Is concomitant quadruple therapy for Helicobacter pylori eradication really needed for Japanese patients?

• 作者: Angelo Zullo Cesare Hassan Vincenzo De Francesco
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HELICOBACTER PYLORI TRIPLE therapy JAPANESE patients
• 年，卷（期）: 2012,（6）
• 页码范围: 103-104
• 页数: 2页
• 分类号: R57

摘要

The study found that the 7 d of concomitant therapy (lansoprazole, amoxicillin, clarithromycin and metronidazole) achieved significantly higher eradication rates compared to 7 d of triple therapy (lansoprazole, amoxicillin, clarithromycin), the intention to treat (ITT) cure rates being 94.9% and 68.3%, respectively. According to our opinion, this study is clinically relevant for Japanese physicians for at least 2 reasons: (1) the standard triple therapy (clarithromycin plus amoxicillin) achieved disappointing cure rates in Japan-in agreement with what was observed in several countries; and (2) the concomitant quadruple therapy is an effective therapeutic alternative.