Synthesis and Influence of Two Quinoxalinone Derivatives on Anxiety- and Depressive-Like Responses in Wistar Rat

• 作者: Abdelhalem Mesfioui Aboubaker Elhessni Ali Ouichou Bouchra Benazzouz Brahim Lakhrissi Fatima Zahra El Mrabet Redouan Nakache
• 来源期刊: 神经系统科学与医药(英文)
• 学科: 医学
• 关键词: DEPRESSION ANXIETY Quinoxalinone DERIVATIVES LOCOMOTOR Activity WISTAR Rats
• 年，卷（期）: 2012,（4）
• 页码范围: 330-336
• 页数: 7页
• 分类号: R73

摘要

Two new quinoxalinone derivatives have been synthesized adopting the HONG method, and investigated for some neuropharmacological effects (anxiety- and depressive-like responses) in rats. The present experiment sought to determine whether treatment with these compounds produces changes in affective responses. We found that the chronic injection of 6-nitro-2(1H)-quinoxalinone (NQu) showed obvious anxiolytic- and antidepressant-like effects, respectively, measured in the behavioral tests of Elevated Plus Maze (EPM) and Forced Swim Test (FST). At the dose of 30 mg/kg, NQu showed a comparative anxiolytic-like effect in rats as diazepam (Dz) (1 mg/kg), and a comparative antidepressant effect as clomipramine (Clmp) (2 mg/kg;i.p). The 2(1H)-quinoxalinone (Qu) significantly reduced depressive-like responses as evaluated in FST, whereas no anxiolytic-like effect was found as measured by open field test (OF). Additionally, the locomotor activity levels were unaffected by treatment as measured by OF and EPM.