Evaluation of the Anti-<i>Trypanosoma Cruzi</i>Effects of the Antipsychotic Drug Levomepromazine

• 作者: Anahí Magdaleno Ariel Mariano Silber Elisabeth Mieko Furusho Pral Inga Eva Stik Lange
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: CHAGAS Disease PHENOTHIAZINES Trypanothione REDUCTASE AMINO Acid Metabolism Chemotherapy
• 年，卷（期）: 2012,（5）
• 页码范围: 344-351
• 页数: 8页
• 分类号: R73

摘要

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a relevant parasitic disease in the Americas. Current chemotherapy relies on Nifurtimox and Benznidazole, which present serious drawbacks, including high toxicity, low efficiency and the emergence of resistant strains. In the present work, the perspectives of levomepromazine, a tri-cyclic compound belonging to the family of phenotiazines with well-known properties as antipsychotics were evaluated as a potential anti-T. cruzi drug. We show that this drug is able to inhibit the proliferation of epimastigotes (IC50 = 0.41 ± 0.01 mM) and to interfere with the infection of the host cells (IC50 = 0.34 ± 0.01 mM). Interestingly, the treatment with levomepromazine affected the ability of metabolites such as glucose, proline and glutamate to fuel the recovery of epi-mastigotes after being submitted to metabolic stress. These findings prompt levomepromazine as a promising leader drug to obtain new trypanocidal activities.