Use of Solid-Supported Reagents towards Synthesis of 2-Arylbenzoxazole, 3, 5-Diarylisoxazole and 1, 3, 5-Triarylpyrazole

• 作者: Sneha Naik Vidya Desai
• 来源期刊: 绿色与可持续化学(英文)
• 学科: 化学
• 关键词: Schiff’s BASES 3 5-Diarylisoxazoles 2-ArylBenzoxazoles 1 5-Triaryl PYRAZOLES Solid-Supported REAGENTS
• 年，卷（期）: 2013,（1）
• 页码范围: 1-7
• 页数: 7页
• 分类号: O6

摘要

Herein we report a convenient and efficient synthesis of 2-Arylbenzoxazole from the Schiff’s bases of 2-Aminophenol, 3, 5-Diarylisoxazole from α, β-unsaturated ketoxime and 1,3,5-Triarylpyrazole from 2-pyrazoline and N-Arylhydrazone by using milder, less toxic and less expensive-NBS-SiO2, KMnO4-Al2O3, PCC-SiO2 and ACC-Al2O3 as solid-supported oxidizing agents at room temperature. Within the framework of Green Chemistry, the use of solid supported reagents has many advantages such as 1) they are easy to remove from reactions by filtration 2) excess reagents can be used to drive the reaction without introducing any difficulties in purification 3) such solid-supported reagents react differently, mostly more selectively, than their unbound counterparts and 4) toxic, noxious and explosive chemicals are handled more safely when contained on solid support.