作者:
基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
The etiology of sudden deafness or idiopathic suddensensorineural hearing loss (ISSHL) remains unclear.Over the past 15 years, we have investigated themechanisms of ischemic-induced hearing loss usinga gerbil model of transient cochlear ischemia. In thegerbil, cochlear ischemia can be induced by occludingthe bilateral vertebral arteries simultaneously at theneck, because the posterior communicating arteries ofthe Circle of Willis close spontaneously around 1 moafter birth. When 15 min ischemia was loaded on thisanimal, permanent hearing loss of about 25 dB andthe death of hair cells, especially inner hair cells wereinduced. These pathological changes were mainly dueto lack of an energy source, glutamate excitotoxicity,and the production of free radicals, especially superoxideand nitrous oxide species. Ischemic damage couldbe prevented by various procedures, such as coolingthe cochlea, intratympanic administration of insulin-likegrowth factor 1 or AM-111 (an anti-apoptotic agent),and systemic administration of prednisolone (steroid),edarabone (free radical scavenger), ginsenoside Rb1(Kanpo), hematopoietic stem cells, glia-cell derivedneurotrophic factor, and liposome-encapsulated hemoglobin(artificial red blood cells). We also found that thecochlea was protected by the ischemic tolerance, indicating catingthat minor cochlear ischemia alleviates or preventsinner ear damage in subsequent severe cochlearischemia. As ISSHL usually occurs suddenly, with nopreceding sign or symptom, we suggest that most ISSHLcases are caused by circulatory disturbance, probablyat the stria vascularis.
推荐文章
An experimental study of interaction between pure water and alkaline feldspar at high temperatures a
Alkaline feldspar
Autoclave
High-temperature and high-pressure experiments
An experimental study on dynamic coupling process of alkaline feldspar dissolution and secondary min
Alkaline feldspar
Dissolution rate
Precipitation
Mineral conversion
Secondary porosity
An experimental study on metal precipitation driven by fluid mixing: implications for genesis of car
Metal precipitation
Fluid mixing
Sulfur species
MVT lead–zinc ore deposits
Carbonate-hosted
lead–zinc deposits
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Experimental study of transient cochlear ischemi a as acause of sudden deafness
来源期刊 世界耳鼻咽喉科杂志 学科 医学
关键词 Sudden DEAFNESS Occlusion of VERTEBRAL artery MONGOLIAN GERBIL Loss of inner hair cell Ischemic tolerance COCHLEAR HYPOTHERMIA
年,卷(期) 2013,(1) 所属期刊栏目
研究方向 页码范围 1-15
页数 15页 分类号 R7
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2013(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
Sudden
DEAFNESS
Occlusion
of
VERTEBRAL
artery
MONGOLIAN
GERBIL
Loss
of
inner
hair
cell
Ischemic
tolerance
COCHLEAR
HYPOTHERMIA
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界耳鼻咽喉科杂志
不定期
2218-6247
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
52
总下载数(次)
0
总被引数(次)
0
论文1v1指导