Blood groups,hemoglobin phenotypes and clinical disorders of consanguineous Yansi population

• 作者: AndréGothot AndréNkebolo Malafu Christiane Gerard Francois Boemer Laurence Seidel Nana Munlemvo Mavanga
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: BLOOD GROUP antigens BLOOD GROUP phenotype Glucose-6-phosphate dehydrogenase deficiency Sickle-cell anemia HEMOGLOBIN electrophoresis CLINICAL DISORDERS CONSANGUINITY Yansi
• 年，卷（期）: 2013,（4）
• 页码范围: 109-114
• 页数: 6页
• 分类号: R

摘要

AIM:To study frequency of blood groups,prevalence of sickle-cell anemia trait and glucose-6-phosphate dehydrogenase deficiency(G6PD),among consanguineous Yansi tribe.METHODS:A total of 525 blood samples were collected,of which 256 among the Yansi population,and 269 for the unrelated control group in the Bandundu province of Democratic Republic of Congo.Blood group antigens were determined in the following systems:ABO,Rh,Kell,Duffy,Kidd and MNS.Blood grouping and extended phenotype tests were performed according to standard immunohematological procedures.Spot tests and tandem mass spectrometry were used respectively for the assessment of G6PD and sickle-cell anemia trait.RESULTS:The frequency of ABO phenotypes conformed to the following order O>A>B>AB with notably 62.5%,23.8%,12.1%and 1.6%for the Yansi,and 54.6%,27.5%,14.1%and 3.7%for the unrelated control group,respectively(P=0.19).As for the Rh phenotypes,the most frequent were ccD.ee,ccD.Ee,CcD.ee,corresponding to 71.5%,12.1%and 12.1%for the Yansi,and 70.6%,15.6%and 8.2%,for the unrelated control group(P=0.27).The frequency of MN and Ss phenotypes were statistically different between groups(P=0.0021 and P=0.0006).G6PD was observed in 11.3%of subjects in the Yansi group,and in 12.4%of controls(P=0.74).The sickle-cell anemia trait was present in 22.4%of Yansi subjects and 17.8%in the control group(P=0.24).Miscarriages and deaths in young age were more common among Yansi people.CONCLUSION:This study shows a significant difference in MNS blood group distribution between the Yansi tribe and a control population.The distribution of other blood groups and the prevalence of hemoglobinopathies did not differ in the Yansi tribe.