Preimplantation genetic diagnosis and the biopsy technique: Important considerations

• 作者: Alessandra Ruberti Daniela Zavaglia Ermanno Greco Gemma Fabozzi Maria Giulia Minasi
• 来源期刊: 生殖科学(英文)
• 学科: 医学
• 关键词: PREIMPLANTATION GENETIC Diagnosis Screening POLAR Body EMBRYO BLASTOCYST BIOPSY
• 年，卷（期）: 2013,（2）
• 页码范围: 7-14
• 页数: 8页
• 分类号: R73

摘要

Preimplantation genetic diagnosis allows to test the genetic status of embryos prior to implantation. In order to obtain genetic material, on which carry out a genetic diagnosis, a procedure named embryo biopsy is required. In the last two decades, embryo biopsy at the cleavage stage has been the mostly performed procedure. However, recently, alternative methods allowing the retrieval of a larger number of cells (blastocyst stage biopsy), or representing a valid alternative to overcome ethical issues (polar body biopsy) have obtained increasing consensus. This article reviews different methods of embryo biopsy and points out their positive and negative aspects.