Dasatinib-Induced Hepatic Dysfunction

• 作者: Arumugam Manoharan
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: DASATINIB HEPATIC DYSFUNCTION REVERSIBILITY
• 年，卷（期）: 2013,（1）
• 页码范围: 8-9
• 页数: 2页
• 分类号: R73

摘要

A 53-year-old man with chronic myeloid leukaemia developed significant hepatic dysfunction when treatment was changed from imatinib (because of drug-induced rash) to dasatinib. Liver function tests returned to normal 77 days after cessation of therapy and have remained normal despite recommencement of dasatinib. Although the pathogenesis for the significant hepatic dysfunction is unclear, this case illustrates the reversibility of this event with dose interruption and that dasatinib can be safely recommenced for ongoing treatment.