Photoisomerization of Provitamin D in Hydrogel Matrix

• 作者: I. E. Boldeskul I. P. Terenetskaya N. A. Pasmurceva P. S. Kapinos T. N. Orlova Yu. M. Samchenko Z. R. Ulberg
• 来源期刊: 软金属(英文)
• 学科: 化学
• 关键词: HYDROGELS Provitamin D PHOTOISOMERIZATION UV Biodosimeter
• 年，卷（期）: 2013,（2）
• 页码范围: 8-12
• 页数: 5页
• 分类号: O6

摘要

Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however, hampers fat-soluble biomolecule incorporation. We synthesized N-isopropylacrylamide (NIPAAm)- and Acrylamide (AA)-based hydrogels with hydrophilic-lipophilic balance that under specific conditions permit homogeneous incorporation of provitamins D3(7-dehydrocholesterol) and D2(ergosterol) dissolved in ethanol. Similarity of provitamins D photoisomerization in such hydrogel matrices with the photoreaction in ethanol shows great potential of the novel material for personal dosimetry of biologically active ‘antirachitic’ UV radiation.