Synthesis and <i>in Vitro</i>Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates

• 作者: Abdelghani El Malki Abderrafia Hafid El Mostapha Rakib Hanan Sekkak Medaghri-Alaoui Abdelouahid
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Nitrile IMINES Cycloaddition PYRAZOLES Cytotoxic Activity
• 年，卷（期）: 2013,（1）
• 页码范围: 37-41
• 页数: 5页
• 分类号: O6

摘要

N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.