Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen

• 作者: Caroline Smith-Burchnell Chris Pickford David C. Pryde Mark Gardner Mike Westby Rob Webster Satish Dayal Stephen M. Shaw Tanya Parkinson Thien-Duc Tran
• 来源期刊: 药物化学期刊(英文)
• 学科: 医学
• 关键词: HCV REPLICON ANTIVIRAL Cell-Based SCREEN
• 年，卷（期）: ywhxqkyw_2013,（1）
• 页码范围: 16-25
• 页数: 10页
• 分类号: R73

摘要

A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were further evaluated, leading to the identification of a series of pyrrolopyridines with excellent antiviral activity in a fully infectious HCV cell-based assay and pharmacokinetic properties.