Short-Term Outcomes in Heart Transplant Recipients Treated with Generic Tacrolimus Compared to Prograf

• 作者: Monica M. Colvin-Adams Peter M. Eckman Vinayak Dhungel
• 来源期刊: 器官移植外科学期刊(英文)
• 学科: 医学
• 关键词: GENERIC TACROLIMUS HEART TRANSPLANT
• 年，卷（期）: 2013,（2）
• 页码范围: 19-21
• 页数: 3页
• 分类号: R6

摘要

Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety of generic tacrolimus, particularly following heart transplant. We performed a retrospective analysis of 21 consecutive patients who were treated with generic tacrolimus following heart transplant and compared rate of biopsy-proven acute cellular rejection to historical controls who were treated with Prograf. No significant difference in biopsy-proven acute cellular rejection was noted between the groups and rates of opportunistic infection and death were comparable. Although limited by the single-center, retrospective design, this preliminary data may be useful to clinicians facing the option of initiating generic tacrolimus following heart transplant.