Role of Th17 cells in the pathogenesis of rheumatoid arthritis

• 作者: Daniel Moynet M Djavad Mossalayi Katia Boniface
• 来源期刊: 世界风湿病学杂志
• 学科: 医学
• 关键词: Interleukin-17-producing CELLS CD4+T CELLS ARTHRITIS Inflammation BIOTHERAPY
• 年，卷（期）: 2013,（3）
• 页码范围: 25-31
• 页数: 7页
• 分类号: R

摘要

Since early description of CD4/CD8 T cell duality,continuous discovery of functional T lymphocyte subsets and their related cytokines constitutes major progress in our understanding of the immune response.T-lymphocyte derived lymphokines and environmental cytokines are essential for both innate and antigen-specific immune responses to a wide variety of agents.Following immune battle and aggression overcome,cytokines may return against neighbored cells/organs,causing pathogenic hypersensitivity reactions,including autoimmune diseases.Due to their cytokine production,CD4+T helper lymphocyte subsets may be considered as one the major players of the immune response.Among CD4+T cell subsets,the identification of interleukin-17-producing cells(Th17)led to better understanding of coordinated cytokine involvement during inflammatory reactions together with the subsequent clarification of complex interactions between these mediators.In this review,we discuss Th17 cell differentiation,functions,and the role of this cell subset during rheumatoid arthritis pathogenesis together with therapeutic strategies to control these cells.