Synthesis of Some <i>N</i>-[(4-Substituted-1-Piperazinyl)-Oxo(Alkyl and Ethylcarbamoyl)]-3-(2-Thiophenyl)Acrylamides as Non-Steroidal Anti-Allergic and Anti-Inflammatory Agents

• 作者: Abdulah A. El-Sawy Ahmed M. Shalaby Mohamed Abdulla Osama I. Abd El-Salam Soha Elshihaby
• 来源期刊: 合成理论与应用(英文)
• 学科: 医学
• 关键词: Thiophene Amino Acids PIPERAZINES Anti-Allergy Ant-Inflammatory
• 年，卷（期）: 2013,（2）
• 页码范围: 63-72
• 页数: 10页
• 分类号: R73

摘要

An interesting approach for the design of anti-allergies is rationally considered. It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. In harmony with these findings, new products 5a-u were synthesized starting from conjugated 2-thiopheneacrylic acid with amino acid esters3a-g followed by coupling of their acid derivatives4a-g with some piperazine segments, with the aim to increase their biological activities and decrease side effects. The anti-allergic and anti-inflammatory activities of the products were evaluated and promising results were obtained.