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AIM:To characterize cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis(IPF)compared to healthy controls.METHODS:Fifty-six IPF patients were involved in the study.The control population consisted of 144 healthy volunteers without history of lung disease.All of the patients were diagnosed with IPF according to the American Thoracic Society/European Respiratory Society consensus statement.Polymorphisms in the interleukin(IL)-1,IL-1,IL-1R,IL-1RA,IL-2,IL-4,IL-6,IL-10,IL-12,tumour necrosis factor,interferon,transforming growth factor,IL-1,IL-2,IL-4 and IL-4RA genes were characterized by polymerase chain reaction with sequence-specific primers.Statistical analysis was performed using the MedCalc statistical software.A Bonferroni correction of significance at an alpha of 0.05 was used for multiple analyses.A corrected P value less than 0.0023(0.05/22)was considered significant.RESULTS:We found significant differences in the IL-4 promoter region polymorphisms between IPF patients and controls.Namely,polymorphisms of IL-4(-590)[computed tomography(CT)in 32 of 56 patients vs 27 of 144 controls;P<0.0001]and IL-4(-33)(CT in 25 of 56 patients vs 27 of 144 controls;P=0.0006)differed between both groups.With regard to haplotypes,we found differences in the frequencies for haplotype 1 of IL-4(-1098)(-590)(-33)between IPF and controls(TCC in 23 of 56,TTC in 10 of 56,and TTT in 21 of 56 patients vs TCC in 112 of 144,TTC in 0 of 144,and TTT in 32 of 144 controls;P<0.0001).We did not find significant differences in gene polymorphism frequencies of other cytokines in the IPF group vs the controls.CONCLUSION:We hypothesize that IL-4 promoter polymorphisms could be involved in the pathogenesis of IPF,likely via enhancement of the Th2 cytokine milieu with exaggerated fibroproliferative healing.
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篇名 Cytokine gene polymorphisms in idiopathic pulmonary fibrosis
来源期刊 世界呼吸病学杂志 学科 医学
关键词 CYTOKINE genes IDIOPATHIC pulmonary FIBROSIS Th2-type IMMUNE response
年,卷(期) 2013,(1) 所属期刊栏目
研究方向 页码范围 1-7
页数 7页 分类号 R
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CYTOKINE
genes
IDIOPATHIC
pulmonary
FIBROSIS
Th2-type
IMMUNE
response
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世界呼吸病学杂志
不定期
2218-6255
北京市朝阳区东四环中路62号楼远洋国际中
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66
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0
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0
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