Circulating microparticles and microRNAs as players in atherosclerosis

• 作者: Adriana Georgescu Nicoleta Alexandru
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: MICROPARTICLES MICRORNA ATHEROSCLEROSIS
• 年，卷（期）: 2013,（2）
• 页码范围: 16-19
• 页数: 4页
• 分类号: R

摘要

Microparticles(MPs)are extracellular membrane vesicles released from normal,apoptotic and pathological cells following a process of detachment from cells of origin.MPs are typically defined by their size,exposure of phosphatidylserine,the expression of surface antigens,proteins and genetic material,originating from their donor cells,and as important vehicles of intercellular communication across numerous biological processes.MPs contain the major source of systemic RNA including microRNA(miRNA)of which aberrant expression appears to be associated with stage and progression of atherosclerosis.The involvement and influence of miRNA during the onset and progression of atherosclerotic disease have generated a lot of est in assessing the feasibility of therapeutic regulation of miRNAs to manipulate them with a special focus on cardiovascular disease.We speculate on the future developments of MPs which contain miRNA as new therapeutic targets for proliferative vascular diseases such as atherosclerosis.