Successful Treatment of Life-Threatening Cerebral Bleeding Associated with Disseminated Intravascular Coagulation Using Recombinant Human Soluble Thrombomodulin in a Patient with Mixed Phenotype Acute Leukemia with t (9;22) (q34;q11.2);<i>Bcr-Abl1</i>

• 作者: Akihisa Nagata Akiyoshi Miwa Naohiro Sekiguchi Naoki Takezako Satoshi Noto Takashi Ishii
• 来源期刊: 临床医学国际期刊(英文)
• 学科: 医学
• 关键词: MIXED PHENOTYPE Acute Leukemia with t (9 22) (q34 q11.2) Bcr-Abl1 RECOMBINANT Human Soluble Thrombomodulin Imatinib Disseminated Intravascular Coagulation
• 年，卷（期）: 2013,（1）
• 页码范围: 52-57
• 页数: 6页
• 分类号: R73

摘要

Recently, mixed phenotype acute leukemia (MPAL) with t (9;22) (q34;q11.2);bcr-abl1 was described as one kind of acute leukemia of ambiguous lineage in the 2008 World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues. However, treatment strategy remains difficult for this uncommon MPAL. In addition, this type of MPAL is at high risk of tumor lysis syndrome (TLS) because of high chemo-sensitivity. Here, we report a MPAL with t (9;22) (q34;q11.2);bcr-abl1 case that suffered from life-threatening cerebral bleeding associated with disseminated intravascular coagulation (DIC) with TLS after bcr-abl positive acute lymphoblastic leukemia (ALL) type induction therapy who was successfully treated with recombinant human thrombomodulin (rhTM). This case reached complete remission without additive cerebral bleeding. In conclusion, bcr-abl positive ALL type induction therapy was effective for MPAL with t (9;22) (q34;q11.2);bcr-abl1 and rhTM was effective against DIC with TLS.