在兔子的网膜的 neovascularization 的过程的脉管的 endothelial 生长因素上的 Lycium Barbarum 多糖和 Danshensu 的影响

• 作者: Bai-Ke Zhang Chun-Lei Wang Hao Guo Rui Wang Shi-Jin Zhang Xue-Min Tian
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: LYCIUM Barbarum POLYSACCHARIDE Dan-shensu vascular ENDOTHELIAL growth factor retinal NEOVASCULARIZATION rabbit
• 年，卷（期）: 2013,（1）
• 页码范围: 59-61
• 页数: 3页
• 分类号: R285

摘要

AIM:To discuss the impact of Lycium Barbarum Polysaccharide (LBP) and Danshensu purified from Traditional Chinese Medicine (TCM) on vascular endothelial growth factor (VEGF) of rabbits with retinal neovascularization. METHODS:Forty rabbits were divided into normal control group, model control group, LBP group and Danshensu group. Animals in the normal control group were fed in the normal oxygen environment. Animals in the other three groups were put into the environment with 70% oxygen for 5 days in order to build the model of oxygen-induced vascular proliferation retinopathy. And then different TCM extract was injected into the abdominal cavities of these annimals. After 7 days, the VEGF content of in the serum of rabbit was measured by double antibody sandwich method. RESULTS:Data analysis indicated that VEGF content was as follows:Danshensu group was lower than model control group (12.92 ±3.84ng/L vs 19.32 ±4.15ng/L, P 【 0.05); LBP group and normal control group were lower than model control group (12.92±3.84ng/L, 9.26±1.61ng/L vs 19.32±4.15ng/L, P【0.01); total blood viscosity, plasma viscosity, cholesterol content, fibrinogen content and triacylglycerol content after peritoneal injection of LBP and Danshensu were obviously lower than before injection. CONCLUSION:TCM extract-LBP and Danshensu can prominently reduce the content of VEGF in the process of vascular proliferative retinopathy of rabbit; can prevent the occurrence of retinal microvascular disease by improving partial oxygen -deficient environment or affecting all kinds of new growth factor.