Testosterone and Its Analogs as a Male Contraceptive

• 作者: Abdul S. Ansari Chandra Shekhar Yadav Nirmal K. Lohiya
• 来源期刊: 性医学进展(英文)
• 学科: 医学
• 关键词: HORMONAL CONTRACEPTION Suppression of SPERMATOGENESIS TESTOSTERONE Androgen-Progestin Combination
• 年，卷（期）: 2013,（3）
• 页码范围: 10-18
• 页数: 9页
• 分类号: R73

摘要

Male contraception by means of hormonal approach was initiated more than 60 years ago when men became azoospermic with administration of testosterone. The basic principle of male hormonal contraception is suppression of spermatogenesis. Exogenous testosterone/testosterone analogs alone or in combination with progestin have been tested for contraceptive efficacy by inhibiting gonadotropins release from pituitary gland. In this review article, advancement in different testosterone preparation tested alone or in combination for contraceptive efficacy has been focused. Administration of testosterone or testosterone analogs alone failed to provide uniform azoospermia or severe oligospermia (gestin combination has proved better contraceptive efficacy than testosterone alone. Further, long term studies with hormonal regimens and other alternative approaches are required with fewer side effects for development of safe and reversible contraceptive.