Viral manipulation of cellular protein conjugation pathways:The SUMO lesson

• 作者: Chiara V Segré Domenico Mattoscio Susanna Chiocca
• 来源期刊: 世界病毒学杂志
• 学科: 医学
• 关键词: VIRUS SMALL ubiquitin-like MODIFIER SMALL ubiquitin-like modifier-ylation Exploitation VIRUS assembly Immune EVASION INNATE immunity
• 年，卷（期）: 2013,（2）
• 页码范围: 79-90
• 页数: 12页
• 分类号: R

摘要

Small ubiquitin-like modifier(SUMO)ylation is a key posttranslational modification mechanism that controls the function of a plethora of proteins and biological processes.Given its central regulatory role,it is not surprising that it is widely exploited by viruses.A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function,to create a cellular environment more favorable for virus survival and propagation,and to prevent host antiviral responses.Since the SUMO pathway is a multi-step cascade,viral proteins engage with it at many levels,to advance and favor each stage of a typical infection cycle:replication,viral assembly and immune evasion.Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle.